Comprehensive Prostate Cancer Care at University Urology
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Prostate Cancer Treatment in Knoxville, TN
Comprehensive, patient-centered care from fellowship-trained urologic oncologists. We offer early detection, advanced diagnostics, individualized focal therapy (HIFU & NanoKnife IRE), radiopharmaceuticals, genetic testing, robotic surgery, and direct nurse navigation—under one roof in East Tennessee.
Expert team
Our fellowship-trained urologic oncologists deliver the region’s most advanced options for screening, diagnostics, and treatment—personalized to your goals.
MRI-fusion & Transperineal Biopsy
We use MRI/ultrasound fusion targeting and a transperineal biopsy approach to improve accuracy and reduce infection risk.
Modern Focal Therapy
We offer both HIFU and NanoKnife IRE, tailoring therapy to each patient’s needs to help preserve urinary and sexual function.
Prostate Cancer Care, from Screening to Survivorship
Screening & Risk Assessment
We provide PSA blood testing and digital rectal exam (DRE), paired with evidence-based risk assessment to guide whether imaging or biopsy is needed.
- Personalized screening plans based on age, risk factors, and prior results
- Shared decision-making with clear discussion of benefits and risks
Advanced Diagnosis
When indicated, we perform transperineal prostate biopsy, which allows precise sampling of MRI-visible targets and systematic zones with lower infection risk compared to the transrectal route.
- MRI/ultrasound fusion targeting
- Comprehensive pathology review
Treatment Options We Offer
Active Surveillance
Close monitoring for low-risk disease with periodic PSA, imaging, and confirmatory biopsies. We intervene only if the cancer shows signs of progression.
Focal Therapy
Targeted treatment with technologies such as HIFU and NanoKnife IRE. These options allow us to individualize care—preserving quality of life while addressing localized tumors.
Robotic Prostatectomy
Robotic-assisted radical prostatectomy with nerve-sparing techniques when appropriate, performed by surgeons with high-volume expertise.
Radiation Therapy Coordination
For patients choosing radiation, we coordinate seamlessly with trusted radiation oncology partners to deliver external beam or brachytherapy plans.
Radiopharmaceutical & Advanced Therapies
We provide access to novel agents such as Pluvicto, Xofigo, and Provenge. These cutting-edge treatments are combined with genetic testing and direct nurse navigation to help you and your family navigate a complex cancer diagnosis.
Focal Therapy: Individualized Options for Localized Prostate Cancer
Focal therapy is designed to target the tumor while sparing surrounding prostate tissue. At University Urology, we offer both High-Intensity Focused Ultrasound (HIFU) and NanoKnife Irreversible Electroporation (IRE). This range of approaches allows us to individualize care based on tumor characteristics, imaging, and patient goals. Our goal is to help preserve urinary continence and sexual function whenever possible, while still treating the cancer effectively.
- Personalized treatment planning based on MRI and biopsy results
- Flexible approach—choosing between HIFU and IRE depending on tumor location and patient priorities
- Ongoing follow-up with PSA and imaging to ensure cancer control
Not every patient is a candidate for focal therapy. Our team will review your complete diagnosis and discuss the role of focal therapy compared with surgery, radiation, or surveillance so you can make an informed choice.
Focal Therapy at a Glance
| Modality | Energy Type | Common Uses | Considerations |
|---|---|---|---|
| HIFU | Focused ultrasound (thermal) | Localized, MRI-visible tumors | Thermal spread must be considered near sensitive structures |
| NanoKnife IRE | Electrical pulses (non-thermal) | Localized, MRI-visible tumors; lesions near nerves/urethra | Requires precise probe placement and mapping |
Talk With a Knoxville Prostate Cancer Expert
Have questions about screening, biopsy, focal therapies, or advanced treatments like Pluvicto, Xofigo, or Provenge? Our team will guide you through your options and help you choose the path that fits your life.
- Same-week consultations often available
- Direct nurse navigation to simplify your care journey
- Multiple locations across East Tennessee
- Most insurances accepted
Frequently Asked Questions
What focal therapy options do you provide?
We offer both HIFU and NanoKnife IRE, allowing us to individualize treatment based on tumor characteristics and patient priorities.
Do you offer radiopharmaceutical therapies?
Yes. We provide access to Pluvicto, Xofigo, and Provenge along with genetic testing and nurse navigation support.
Can treatments be combined or sequenced?
Yes. Depending on your cancer stage and progression, treatments can be integrated—including surgery, radiation, focal therapies, systemic therapy, and radiopharmaceuticals.