advanced bladder cancer knoxville

Advanced Bladder Cancer Treatments in Knoxville, TN

University Urology is the highest-volume, most experienced practice in the Knoxville region for the diagnosis and treatment of bladder cancer. Patients across East Tennessee choose us for comprehensive, guidelines-based care and access to the latest therapies—without the need to travel outside the greater Knoxville area.

Comprehensive Treatment Options

We offer the full spectrum of advanced bladder cancer treatments, including FDA-approved therapies, novel immunotherapies, and organ-sparing approaches. Our team of fellowship-trained urologic oncologists ensures that each patient receives the most appropriate, personalized care.

BCG Therapy in Knoxville

BCG (Bacillus Calmette-Guérin) remains a cornerstone of treatment for non–muscle-invasive bladder cancer. At University Urology, we maintain active BCG availability, even during times of national shortage, to ensure our patients receive this critical therapy.

Next-Generation Immunotherapy: Anktiva

Anktiva (N-803) is an innovative immunotherapy designed to enhance BCG response in patients with high-risk bladder cancer. University Urology provides access to this therapy for eligible patients, aligning care with the latest clinical trial evidence and national guidelines.

Gene Therapy: Adstiladrin

Adstiladrin (nadofaragene firadenovec) is a novel gene therapy approved for BCG-unresponsive non–muscle-invasive bladder cancer. Delivered directly into the bladder, it stimulates the immune system to attack cancer cells. Our team is experienced in safely administering this cutting-edge option.

Targeted Therapy: Zusduri

Zusduri (mitomycin reverse thermal gel) is a new, FDA-approved intravesical therapy for patients with low-grade, intermediate-risk non–muscle-invasive bladder cancer. This innovative gel is instilled directly into the bladder as a liquid, where it becomes a gel at body temperature, allowing prolonged contact with the bladder lining. The extended exposure time helps improve treatment effectiveness while preserving bladder function.

Organ-Sparing Treatments for Upper Tract Urothelial Cancer

Whenever possible, we pursue organ-sparing approaches to preserve kidney function in patients with upper tract urothelial carcinoma (UTUC). Options include:

  • Endoscopic laser ablation of tumors
  • Topical chemotherapy instillations into the upper tract
  • Use of drug delivery systems designed for urothelial preservation

These advanced approaches allow many patients to avoid radical surgery while still receiving effective cancer treatment.

Why Choose University Urology?

  • Most experienced bladder cancer team in Knoxville and East Tennessee
  • Highest-volume center for bladder cancer care in the region
  • Access to all modern therapies including BCG, Anktiva, Adstiladrin, Zusduri
  • Organ-sparing expertise for upper tract urothelial cancer
  • No need to travel outside Knoxville for world-class bladder cancer treatment

Schedule Your Consultation

If you or a loved one has been diagnosed with bladder cancer, University Urology offers the most advanced and up-to-date treatment options in Knoxville. Our goal is to provide compassionate, expert care close to home.

📞 Call Us: 865.305.9254
📍 Locations: Multiple convenient offices across East Tennessee