For Patients · University Urology, PC
Axonics / Sacral Neuromodulation — PNE Trial Preparation
Instructions for your peripheral nerve evaluation (PNE) trial — the first step in sacral neuromodulation treatment for overactive bladder, urinary incontinence, or urinary retention.
Understanding Your Trial
What the PNE Trial Involves
The PNE trial is a temporary test to determine whether sacral neuromodulation will be effective for you before committing to permanent implant surgery. A thin wire is placed near the sacral nerve under local anesthetic and connected to an external stimulator worn for 3–7 days while you track your symptoms.
Wire placement (in office)
A temporary lead wire is placed near your S3 sacral nerve under local anesthetic. The wire connects to a small external stimulator worn on your body.
Trial period at home (3–7 days)
You go home with the external stimulator and keep a voiding diary tracking symptoms daily. Most patients describe a tingling or tapping sensation in the pelvic area.
Return visit and evaluation
You return for wire removal and review of your voiding diary. If symptoms improved by 50% or more, you are a candidate for permanent Axonics implant surgery.
Before Your PNE Trial
Preparation
Take your prescribed antibiotic
Take the prescribed antibiotic before the procedure as directed.
Arrange a driver
You will need someone to drive you home after wire placement.
Wear loose, comfortable clothing
Wear loose pants or a skirt. Tight waistbands can irritate the wire exit site.
Keep a voiding diary during the trial
You will be given a voiding diary to complete during the trial. Accurate entries are essential for evaluating whether the trial was successful. Bring the diary to your removal appointment.
Blood Thinner / Anticoagulation Medications
Contact your prescribing physician before stopping any blood thinner or anticoagulant. Do not stop these medications without medical guidance, particularly if you are on anticoagulation for a high-risk condition such as atrial fibrillation, a mechanical heart valve, or a recent blood clot.
- Aspirin — hold 7 days
- Clopidogrel (Plavix) — hold 5–7 days
- Apixaban (Eliquis) — hold 48 hours
- Rivaroxaban (Xarelto) — hold 48 hours
- Warfarin (Coumadin) — contact prescribing physician for INR guidance
During the Trial
Living With the Trial Wire
Important restrictions
Call us if you experience:
Call (865) 305-9254. After hours, follow prompts for on-call provider.
Common Questions
Frequently Asked Questions
What does the stimulation feel like?
Most patients describe a mild tingling, tapping, or vibrating sensation in the perineum, buttocks, or inner thigh. It should not be painful. Your provider will adjust settings to a comfortable level before you leave.
What if the trial is successful?
If symptoms improve by 50% or more, you are a candidate for permanent Axonics implant surgery. Your provider will discuss the surgical procedure and recovery at your removal visit.
What if the trial does not work?
The wire is simply removed in the office. There is no lasting effect and no commitment to further treatment. Your provider will discuss alternative options.
Questions Before Your PNE Trial?
Send a Klara message or call us. Our team is happy to walk you through what to expect.